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Review
. 2012 Mar;58(3):327-33.
doi: 10.1002/pbc.23341. Epub 2011 Oct 11.

Of dogs and men: comparative biology as a tool for the discovery of novel biomarkers and drug development targets in osteosarcoma

Kenneth S Rankin  1 , Mike Starkey, John Lunec, Craig H Gerrand, Sue Murphy, Swethajit Biswas
Affiliations
Review

Of dogs and men: comparative biology as a tool for the discovery of novel biomarkers and drug development targets in osteosarcoma

Kenneth S Rankin et al. Pediatr Blood Cancer. 2012 Mar.

Abstract

The similarities between human and canine osteosarcoma with regard to histology, biological behavior and molecular genetic alterations suggest that the dog provides a supplementary model for the development and preclinical testing of novel therapeutics. Counter intuitively, careful examination of the differences between OS in the two species may also be rewarding in terms of increasing our understanding of the pathogenesis of this cancer. This review will discuss the arguments in favor of the "dog model" and outline how the evaluation of treatment strategies in dogs has indicated avenues for improvement of protocols for human patients.

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