Molecular structure of VDM-11, CAS Number: 313998-81-1
VDM-11 (CAS 313998-81-1)
Application:
VDM-11 is a selective inhibitor of the anandamide membrane transporter
CAS Number:
313998-81-1
Purity:
98%
Molecular Weight:
409.6
Molecular Formula:
C27H39NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
VDM-11 is a small molecule inhibitor of the anandamide membrane transporter (AMT), the enzyme responsible for cellular reuptake of the endogenous cannabinoid Anandamide (sc-200790). Inhibition of Anandamide uptake by VDM-11 blocks inactivation of the endocannabinoid signal, and this maintenance of Anandamide concentration has been demonstrated to confer CB1-mediated inhibition of tumor proliferation. VDM-11 shows no agonist activity at the TRPV1 receptor as other Anandamide-mimic AMT inhibitors have been reported to do. VDM-11 is an inhibitor of FAAH and Monoglyceride Lipase.
VDM-11 (CAS 313998-81-1) References:
- Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity. | De Petrocellis, L., et al. 2000. FEBS Lett. 483: 52-6. PMID: 11033355
- The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism. | De Petrocellis, L., et al. 2001. J Biol Chem. 276: 12856-63. PMID: 11278420
- Experimental parkinsonism alters endocannabinoid degradation: implications for striatal glutamatergic transmission. | Gubellini, P., et al. 2002. J Neurosci. 22: 6900-7. PMID: 12177188
- AM404 and VDM 11 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide. | Jonsson, KO., et al. 2003. Arch Toxicol. 77: 201-7. PMID: 12698235
- Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasis. | Portella, G., et al. 2003. FASEB J. 17: 1771-3. PMID: 12958205
- Characterization of an anandamide degradation system in prostate epithelial PC-3 cells: synthesis of new transporter inhibitors as tools for this study. | Ruiz-Llorente, L., et al. 2004. Br J Pharmacol. 141: 457-67. PMID: 14718261
- A new strategy to block tumor growth by inhibiting endocannabinoid inactivation. | Bifulco, M., et al. 2004. FASEB J. 18: 1606-8. PMID: 15289448
- Effect of repeated systemic administration of selective inhibitors of endocannabinoid inactivation on rat brain endocannabinoid levels. | de Lago, E., et al. 2005. Biochem Pharmacol. 70: 446-52. PMID: 15963472
- Endocannabinoids and beta-amyloid-induced neurotoxicity in vivo: effect of pharmacological elevation of endocannabinoid levels. | van der Stelt, M., et al. 2006. Cell Mol Life Sci. 63: 1410-24. PMID: 16732431
- The anandamide membrane transporter inhibitor, VDM-11, modulates sleep and c-Fos expression in the rat brain. | Murillo-Rodríguez, E., et al. 2008. Neuroscience. 157: 1-11. PMID: 18822353
- Evidence for both inverse agonism at the cannabinoid CB1 receptor and the lack of an endogenous cannabinoid tone in the rat and guinea-pig isolated ileum myenteric plexus-longitudinal muscle preparation. | Makwana, R., et al. 2010. Br J Pharmacol. 160: 615-26. PMID: 20590566
- The administration of endocannabinoid uptake inhibitors OMDM-2 or VDM-11 promotes sleep and decreases extracellular levels of dopamine in rats. | Murillo-Rodríguez, E., et al. 2013. Physiol Behav. 109: 88-95. PMID: 23238438
- Revealing the role of the endocannabinoid system modulators, SR141716A, URB597 and VDM-11, in sleep homeostasis. | Murillo-Rodríguez, E., et al. 2016. Neuroscience. 339: 433-449. PMID: 27746343
VDM-11 (313998-81-1) Modulation Targets
Inhibitor of:
FAAH, MIP-1β, and Monoglyceride Lipase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VDM-11, 10 mg | sc-200371 | 10 mg | $120.00 | |||
VDM-11, 50 mg | sc-200371A | 50 mg | $500.00 |