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Clinical Trial
. 1999 Jan;71(1):35-9.
doi: 10.1016/s0015-0282(98)00417-8.

Spontaneous conception after the birth of infants conceived through in vitro fertilization treatment

Y Shimizu  1 , H Kodama, J Fukuda, M Murata, J Kumagai, T Tanaka
Affiliations
Free article
Clinical Trial

Spontaneous conception after the birth of infants conceived through in vitro fertilization treatment

Y Shimizu et al. Fertil Steril. 1999 Jan.
Free article

Abstract

Objective: To investigate the incidence of spontaneous conception after the birth of infants conceived through IVF in couples with subfertility caused by endometriosis, a mild male factor, or unexplained factors, and to identify clinical conditions related to the occurrence of spontaneous conception.

Design: Retrospective analysis.

Setting: Department of Obstetrics and Gynecology, Akita University School of Medicine, Akita, Japan.

Patient(s): One hundred forty-two women who conceived through IVF and 25 of the 142 women who subsequently conceived spontaneously.

Intervention(s): Patient characteristics and IVF data were obtained from hospital records, and follow-up data were collected through telephone interviews.

Main outcome measure(s): Cumulative conception rate.

Result(s): The cumulative conception rate at 60 months after the delivery of infants conceived through IVF was 18%, with most conceptions occurring within 2 years of delivery. Proportional hazard analysis indicated that patient age was the most important clinical variable related to the occurrence of spontaneous conception.

Conclusion(s): This study provides information that will be useful in counseling subfertile couples who have conceived through the use of IVF.

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