Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1997 Jun 27;276(5321):2037-9.
doi: 10.1126/science.276.5321.2037.

In vivo endoscopic optical biopsy with optical coherence tomography

G J Tearney  1 , M E Brezinski, B E Bouma, S A Boppart, C Pitris, J F Southern, J G Fujimoto
Affiliations

In vivo endoscopic optical biopsy with optical coherence tomography

G J Tearney et al. Science. .

Abstract

Current medical imaging technologies allow visualization of tissue anatomy in the human body at resolutions ranging from 100 micrometers to 1 millimeter. These technologies are generally not sensitive enough to detect early-stage tissue abnormalities associated with diseases such as cancer and atherosclerosis, which require micrometer-scale resolution. Here, optical coherence tomography was adapted to allow high-speed visualization of tissue in a living animal with a catheter-endoscope 1 millimeter in diameter. This method, referred to as "optical biopsy," was used to obtain cross-sectional images of the rabbit gastrointestinal and respiratory tracts at 10-micrometer resolution.

PubMed Disclaimer

Comment in

  • Tissue optics.
    Benaron DA, Cheong WF, Stevenson DK. Benaron DA, et al. Science. 1997 Jun 27;276(5321):2002-3. doi: 10.1126/science.276.5321.2002. Science. 1997. PMID: 9221510 No abstract available.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

LinkOut - more resources