doi: 10.1074/jbc.270.41.23934.
Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1
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- PMID: 7592586
- DOI: 10.1074/jbc.270.41.23934
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Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1
J Biol Chem.
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Free article
Abstract
The stress-activated p38 mitogen-activated protein (MAP) kinase defines a subgroup of the mammalian MAP kinases that appear to play a key role in regulating inflammatory responses. Co-expression of constitutively active forms of Rac and Cdc42 leads to activation of p38 while dominant negative Rac and Cdc42 inhibit the ability of interleukin-1 to increase p38 activity. p21-activated kinase 1 (Pak1) is a potential mediator of Rac/Cdc42 signaling, and we observe that Pak1 stimulates p38 activity. A dominant negative Pak1 suppresses both interleukin-1- and Rac/Cdc42-induced p38 activity. Rac and Cdc42 appear to regulate a protein kinase cascade initiated at the level of Pak and leading to activation of p38 and JNK.
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