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. 2020 Dec;13(4):381-392.
doi: 10.1007/s12200-020-1096-x. Epub 2020 Dec 23.

Line-field confocal optical coherence tomography for three-dimensional skin imaging

Jonas Ogien  1 , Anthony Daures  1 , Maxime Cazalas  1 , Jean-Luc Perrot  2 , Arnaud Dubois  3
Affiliations

Line-field confocal optical coherence tomography for three-dimensional skin imaging

Jonas Ogien et al. Front Optoelectron. 2020 Dec.

Abstract

This paper reports on the latest advances in line-field confocal optical coherence tomography (LC-OCT), a recently invented imaging technology that now allows the generation of either horizontal (x × y) section images at an adjustable depth or vertical (x × z) section images at an adjustable lateral position, as well as three-dimensional images. For both two-dimensional imaging modes, images are acquired in real-time, with real-time control of the depth and lateral positions. Three-dimensional (x × y × z) images are acquired from a stack of horizontal section images. The device is in the form of a portable probe. The handle of the probe has a button and a scroll wheel allowing the user to control the imaging modes. Using a supercontinuum laser as a broadband light source and a high numerical microscope objective, an isotropic spatial resolution of ∼1 µm is achieved. The field of view of the three-dimensional images is 1.2 mm × 0.5 mm × 0.5 mm (x × y × z). Images of skin tissues are presented to demonstrate the potential of the technology in dermatology.

Keywords: dermatology; microscopy; optical coherence tomography (OCT); three-dimensional imaging.

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References

    1. Fercher A F. Optical coherence tomography. Journal of Biomedical Optics. 1996;1(2):157–173. doi: 10.1117/12.231361. - DOI - PubMed
    1. Podoleanu A G. Optical coherence tomography. Journal of Microscopy. 2012;247(3):209–219. doi: 10.1111/j.1365-2818.2012.03619.x. - DOI - PMC - PubMed
    1. Zysk A M, Nguyen F T, Oldenburg A L, Marks D L, Boppart S A. Optical coherence tomography: a review of clinical development from bench to bedside. Journal of Biomedical Optics. 2007;12(5):051403. doi: 10.1117/1.2793736. - DOI - PubMed
    1. Schuman J S, Puliafito C A, Fujimoto J G, Duker J S. Optical Coherence Tomography of Ocular Diseases. 3rd ed. New Jersey: Slack Inc.; 2013.
    1. Bezerra H G, Costa M A, Guagliumi G, Rollins A M, Simon D I. Intracoronary optical coherence tomography: a comprehensive review clinical and research applications. JACC: Cardiovascular Interventions. 2009;2(11):1035–1046. - PMC - PubMed

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