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Review
. 2021 Jul;21(4):395-409.
doi: 10.1007/s40256-020-00450-w. Epub 2020 Nov 10.

A Review of Bivalirudin for Pediatric and Adult Mechanical Circulatory Support

Tori Taylor  1 , Christopher T Campbell  2 , Brian Kelly  3
Affiliations
Review

A Review of Bivalirudin for Pediatric and Adult Mechanical Circulatory Support

Tori Taylor et al. Am J Cardiovasc Drugs. 2021 Jul.

Abstract

As the use of mechanical circulatory support has increased in volume and complexity, anticoagulation remains an intricate component of a patient's pharmacotherapy plan. Traditionally, heparin has been the primary anticoagulant utilized because of its ease of titration and familiarity of use. More recently, bivalirudin, a direct thrombin inhibitor, has attracted attention as a potential alternative to traditional therapy. While labeled for use in percutaneous coronary interventions, it is utilized off-label for heparin-induced thrombocytopenia and mechanical circulatory support. A literature search identified ten studies in which bivalirudin was used in extracorporeal membrane oxygenation and five studies in which it was used in ventricular assist devices. The purpose of this review was to summarize the currently available literature for bivalirudin use for mechanical circulatory support in both adult and pediatric patients.

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Conflict of interest statement

Tori Taylor, Christopher T. Campbell, and Brian Kelly have no conflicts of interest that are directly relevant to the content of this article.

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