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Dietary Reference Values for riboflavin

EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) et al. EFSA J. .

Abstract

Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) derives dietary reference values (DRVs) for riboflavin. The Panel considers that the inflection point in the urinary riboflavin excretion curve in relation to riboflavin intake reflects body saturation and can be used as a biomarker of adequate riboflavin status. The Panel also considers that erythrocyte glutathione reductase activation coefficient is a useful biomarker, but has limitations. For adults, the Panel considers that average requirements (ARs) and population reference intakes (PRIs) can be determined from the weighted mean of riboflavin intake associated with the inflection point in the urinary riboflavin excretion curve reported in four intervention studies. PRIs are derived for adults and children assuming a coefficient of variation of 10%, in the absence of information on the variability in the requirement and to account for the potential effect of physical activity and the methylenetetrahydrofolate reductase 677TT genotype. For adults, the AR and PRI are set at 1.3 and 1.6 mg/day. For infants aged 7-11 months, an adequate intake of 0.4 mg/day is set by upward extrapolation from the riboflavin intake of exclusively breastfed infants aged 0-6 months. For children, ARs are derived by downward extrapolation from the adult AR, applying allometric scaling and growth factors and considering differences in reference body weight. For children of both sexes aged 1-17 years, ARs range between 0.5 and 1.4 mg/day, and PRIs between 0.6 and 1.6 mg/day. For pregnant or lactating women, additional requirements are considered, to account for fetal uptake and riboflavin accretion in the placenta during pregnancy or the losses through breast milk, and PRIs of 1.9 and 2.0 mg/day, respectively, are derived.

Keywords: average requirement; biomarker; dietary reference value; glutathione reductase; population reference intake; riboflavin; urinary excretion.

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Figures

Figure 1
Figure 1
Chemical structures of riboflavin, FMN and FAD

  1. Molecular masses: riboflavin: 376.4 g/mol; FMN: 456.3 g/mol, FAD: 785.6 g/mol.

See this image and copyright information in PMC

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References

    1. Abrahamsen B, Madsen JS, Tofteng CL, Stilgren L, Bladbjerg EM, Kristensen SR, Brixen K and Mosekilde L, 2005. Are effects of MTHFR (C677T) genotype on BMD confined to women with low folate and riboflavin intake? Analysis of food records from the Danish osteoporosis prevention study. Bone, 36, 577–583. - PubMed
    1. Adamson JD, Jolliffe N, Kruse HD, Lowry OH, Moore PE, Platt BS, Sebrell WH, Tice JW, Tisdall FF, Wilder RM and Zamecnik PC, 1945. Medical Survey of Nutrition in Newfoundland. Canadian Medical Association Journal, 52, 227–250. - PMC - PubMed
    1. Afssa (Agence française de sécurité sanitaire des aliments) , 2001. Apports nutritionnels conseillés pour la population française. Editions Tec & Doc, Paris, France, 605 pp.
    1. Agte V, Jahagirdar M and Chiplonkar S, 2005. Apparent absorption of eight micronutrients and phytic acid from vegetarian meals in ileostomized human volunteers. Nutrition, 21, 678–685. - PubMed
    1. Ajayi OA, Okike OC and Yusuf Y, 1990. Haematological response to supplements of riboflavin and ascorbic acid in Nigerian young adults. European Journal of Haematology, 44, 209–212. - PubMed

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