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Case Reports
. 2017;56(6):737-739.
doi: 10.2169/internalmedicine.56.7727. Epub 2017 Mar 17.

Metoclopramide-induced Serotonin Syndrome

Taku Harada  1 , Takanobu Hirosawa, Kouhei Morinaga, Taro Shimizu
Affiliations
Case Reports

Metoclopramide-induced Serotonin Syndrome

Taku Harada et al. Intern Med. 2017.

Abstract

A 40-year-old woman with bipolar disorder who was taking mirtazapine presented with mydriasis, abnormal diaphoresis, myoclonus and muscle rigidity after taking metocloplamide. Her medical history, which included the use of serotonergic agents, and the presence of symptoms including myoclonus and muscle rigidity were consistent with a diagnosis of serotonin syndrome (SS) according to the Hunter criteria. The symptoms diminished following three days of treatment with oral lorazepam and cyproheptadine and a reduced dose of mirtazapine. Metoclopramide is frequently used to various gastric symptom. Metoclopramide is not widely known to induce SS. This potentially fatal condition should be avoided by exercising care in the use of drugs that have the potential to cause drug-drug interactions.

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