Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Feb 27;22(3):368.
doi: 10.3390/molecules22030368.

The Pharmaceutical Industry in 2016. An Analysis of FDA Drug Approvals from a Perspective of the Molecule Type

Beatriz G de la Torre  1 , Fernando Albericio  2   3   4
Affiliations
Review

The Pharmaceutical Industry in 2016. An Analysis of FDA Drug Approvals from a Perspective of the Molecule Type

Beatriz G de la Torre et al. Molecules. .

Abstract

This is an analysis from a chemical point of view of the 22 drugs accepted by the FDA during 2016. The different drugs from the 2016 "harvest" have been classified according to their chemical structure: antibodies; TIDES (oligonucleotides and peptides); amino acids and natural products; drug combination; and small molecules.

Keywords: API; biologics; chemical entities; drug discovery; peptide; small molecules.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
New Chemical Entities and Biologics approved by the FDA in the last two decades [3,4].
Figure 2
Figure 2
General structure of oligonucleotide-based drugs. Standard RNA strand (A); Phosphorothioate backbone (B); Morpholino Phosphorodiamidate backbone (C); Standard DNA strand (D).
Figure 3
Figure 3
Structure of Adlyxin.
Figure 4
Figure 4
Structures of Xiidra (A); Briviact (B); Auxim (C); and Ocaliva (D).
Figure 5
Figure 5
Structures and composition of Zepatier (A) and Epclusa (B).
Figure 6
Figure 6
Structures of Rubraca (A); Eucrisa (B); Nuplazid (C); and Venclexta (D).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Yuan H., Ma Q., Ye L., Piao G. The traditional medicine and modern medicine from natural products. Molecules. 2016;21 doi: 10.3390/molecules21050559. - DOI - PMC - PubMed
    1. Joint Research Centre European Commission . The 2016 EU Industrial R&D Investment Scoreboard. Publications Office of the EU; London, UK: 2016.
    1. U.S. Food and Drug Administration (FDA) [(accessed on 5 February 2017)]; Available online: http://www.accessdata.fda.gov/scripts/cder/daf/
    1. Mullard A. 2016 FDA drug approvals. Nat. Rev. Drug Discov. 2017;16:73–76. doi: 10.1038/nrd.2017.14. - DOI - PubMed
    1. Jarvis L.M. The Year in New Drugs. Chemical & Engineering News; Washington, DC, USA: 2017. pp. 28–32.

MeSH terms