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Review
. 2016 Jul;95(27):e4147.
doi: 10.1097/MD.0000000000004147.

Thr105Ile (rs11558538) polymorphism in the histamine N-methyltransferase (HNMT) gene and risk for Parkinson disease: A PRISMA-compliant systematic review and meta-analysis

Félix Javier Jiménez-Jiménez  1 , Hortensia Alonso-Navarro, Elena García-Martín, José A G Agúndez
Affiliations
Review

Thr105Ile (rs11558538) polymorphism in the histamine N-methyltransferase (HNMT) gene and risk for Parkinson disease: A PRISMA-compliant systematic review and meta-analysis

Félix Javier Jiménez-Jiménez et al. Medicine (Baltimore). 2016 Jul.

Abstract

Background/aims: Several neuropathological, biochemical, and pharmacological data suggested a possible role of histamine in the etiopathogenesis of Parkinson disease (PD). The single nucleotide polymorphism (SNP) rs11558538 in the histamine N-methyltransferase (HNMT) gene has been associated with the risk of developing PD by several studies but not by some others. We carried out a systematic review that included all the studies published on PD risk related to the rs11558538 SNP, and we conducted a meta-analysis following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.

Methods: We used several databases to perform the systematic review, the software Meta-DiSc 1.1.1 to perform the meta-analysis of the eligible studies, and the Q-statistic to test heterogeneity between studies.

Results: The meta-analysis included 4 eligible case-control association studies for the HNMT rs11558538 SNP and the risk for PD (2108 patients, 2158 controls). The frequency of the minor allele positivity showed a statistically significant association with a decreased risk for PD, both in the total series and in Caucasians. Although homozygosity for the minor allele did not reach statistical significance, the test for trend indicates the occurrence of a gene-dose effect. Global diagnostic odds ratios (95% confidence intervals) for rs11558538T were 0.61 (0.46-0.81) for the total group, and 0.63 (0.45-0.88) for Caucasian patients.

Conclusion: The present meta-analysis confirms published evidence suggesting that the HNMT rs11558538 minor allele is related to a reduced risk of developing PD.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Flowchart of the study selection.
Figure 2
Figure 2
Diagnostic odds ratios and 95% CIs for each study and for pooled samples for carriers of the rs11558538T allele in patients with PD and controls in total series (A) and in Caucasian patients (B). CI = confidence interval, PD = Parkinson disease.
Figure 3
Figure 3
Diagnostic odds ratios and 95% CIs for each study and for pooled samples for carriers of the rs11558538C allele in patients with PD and controls in total series (A) and in Caucasian patients (B). CI = confidence interval, PD = Parkinson disease.
Figure 4
Figure 4
Diagnostic odds ratios and 95% CIs for each study and for pooled samples of rs11558538T allele (minor allele) in patients with PD and controls in total series (A) and in Caucasian patients (B). CI = confidence interval, PD = Parkinson disease.
Figure 5
Figure 5
Diagnostic odds ratios and 95% CIs for each study and for pooled samples of rs11558538C allele (major allele) in patients with PD and controls in total series (A) and in Caucasian patients (B). CI = confidence interval, PD = Parkinson disease.
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