Guideline for the Treatment of Breakthrough and the Prevention of Refractory Chemotherapy-Induced Nausea and Vomiting in Children With Cancer

doi:10.1002/pbc.25955

Review

. 2016 Jul;63(7):1144-51.

doi: 10.1002/pbc.25955. Epub 2016 Mar 9.

Guideline for the Treatment of Breakthrough and the Prevention of Refractory Chemotherapy-Induced Nausea and Vomiting in Children With Cancer

Jacqueline Flank^{1

2}, Paula D Robinson³, Mark Holdsworth⁴, Robert Phillips^{5

6}, Carol Portwine⁷, Paul Gibson⁸, Cathy Maan⁸, Nancy Stefin⁷, Lillian Sung^{9

10}, L Lee Dupuis^{1

2

10}

Affiliations

¹ Department of Pharmacy, The Hospital for Sick Children, Toronto, Canada.
² Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada.
³ Pediatric Oncology Group of Ontario, Toronto, Canada.
⁴ College of Pharmacy, University of New Mexico, Albuquerque, New Mexico.
⁵ Regional Department of Haematology and Oncology, Leeds Children's Hospital, Leeds, United Kingdom.
⁶ Centre for Reviews and Dissemination, University of York, York, United Kingdom.
⁷ Division of Hematology/Oncology, Department of Pediatrics, McMaster University, Hamilton, Canada.
⁸ Pediatric Hematology/Oncology, Children's Hospital, London Health Sciences Centre, London, Canada.
⁹ Department of Paediatrics, Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Canada.
¹⁰ Research Institute, The Hospital for Sick Children, Toronto, Canada.

PMID: 26960036
DOI: 10.1002/pbc.25955

Review

Guideline for the Treatment of Breakthrough and the Prevention of Refractory Chemotherapy-Induced Nausea and Vomiting in Children With Cancer

Jacqueline Flank et al. Pediatr Blood Cancer. 2016 Jul.

. 2016 Jul;63(7):1144-51.

doi: 10.1002/pbc.25955. Epub 2016 Mar 9.

Authors

Affiliations

¹ Department of Pharmacy, The Hospital for Sick Children, Toronto, Canada.
² Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada.
³ Pediatric Oncology Group of Ontario, Toronto, Canada.
⁴ College of Pharmacy, University of New Mexico, Albuquerque, New Mexico.
⁵ Regional Department of Haematology and Oncology, Leeds Children's Hospital, Leeds, United Kingdom.
⁶ Centre for Reviews and Dissemination, University of York, York, United Kingdom.
⁷ Division of Hematology/Oncology, Department of Pediatrics, McMaster University, Hamilton, Canada.
⁸ Pediatric Hematology/Oncology, Children's Hospital, London Health Sciences Centre, London, Canada.
⁹ Department of Paediatrics, Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Canada.
¹⁰ Research Institute, The Hospital for Sick Children, Toronto, Canada.

PMID: 26960036
DOI: 10.1002/pbc.25955

Abstract

This clinical practice guideline provides an approach to the treatment of breakthrough chemotherapy-induced nausea and vomiting (CINV) and the prevention of refractory CINV in children. It was developed by an international, interprofessional panel and is based on systematic literature reviews. Evidence-based interventions for the treatment of breakthrough and prophylaxis of refractory CINV are recommended. Gaps in the evidence used to support the recommendations made in this clinical practice guideline were identified. The contribution of these recommendations to breakthrough and refractory CINV control in children requires prospective evaluation.

Keywords: chemotherapy-induced nausea; chemotherapy-induced vomiting; clinical practice guideline; supportive care.

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Guideline for the Treatment of Breakthrough and the Prevention of Refractory Chemotherapy-Induced Nausea and Vomiting in Children With Cancer

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Guideline for the Treatment of Breakthrough and the Prevention of Refractory Chemotherapy-Induced Nausea and Vomiting in Children With Cancer

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