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Meta-Analysis
. 2015 Nov 8:21:3420-6.
doi: 10.12659/msm.896018.

Association of Vitamin E Intake with Reduced Risk of Kidney Cancer: A Meta-Analysis of Observational Studies

Chongxing Shen  1 , Ying Huang  2 , Shanhong Yi  1 , Zhenqiang Fang  1 , Longkun Li  1
Affiliations
Meta-Analysis

Association of Vitamin E Intake with Reduced Risk of Kidney Cancer: A Meta-Analysis of Observational Studies

Chongxing Shen et al. Med Sci Monit. .

Abstract

Background: Several observational studies suggested that vitamin E intake is related to the risk of kidney cancer; however, the results of published studies are inconsistent.

Material and methods: A meta-analysis was performed to assess the relationship between vitamin E intake and the risk of kidney cancer by searching PubMed and Medline through August 2015. We computed pooled relative risks (RR) and 95%CI of kidney cancer for the highest versus lowest level of vitamin E intake.

Results: A total of 13 observational studies (7 case-control and 6 cohort) were included. The pooled RR (95%CI) of kidney cancer for the highest vs. the lowest level of vitamin E intake was 0.81 (0.69-0.94). In subgroup-analysis, this study found an inverse relationship between vitamin E intake and kidney cancer risk, which was not significantly modified by study design, study population, or sex distribution except in the cohort studies.

Conclusions: Results of the present study suggest an inverse relationship between vitamin E intake and kidney cancer risk. However, additional well designed cohort studies and randomized controlled trials that focus on the relationship between vitamin E intake and kidney cancer risk are needed.

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Figures

Figure 1
Figure 1
Forest plot shows the relationship between vitamin E intake and kidney cancer risk.
Figure 2
Figure 2
The result of sensitivity analysis.
Figure 3
Figure 3
Forest plot for publication bias.
Figure 4
Figure 4
The results of subgroup-analysis according to study design.
Figure 5
Figure 5
The results of subgroup analysis according to study population.
Figure 6
Figure 6
The results of subgroup analysis according to sex distribution.
See this image and copyright information in PMC

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