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. 2011 Apr;71(4):497-503.
doi: 10.1111/j.1365-2125.2010.03854.x.

Drug discovery: lessons from evolution

John Warren  1
Affiliations

Drug discovery: lessons from evolution

John Warren. Br J Clin Pharmacol. 2011 Apr.

Abstract

A common view within the pharmaceutical industry is that there is a problem with drug discovery and we should do something about it. There is much sympathy for this from academics, regulators and politicians. In this article I propose that lessons learnt from evolution help identify those factors that favour successful drug discovery. This personal view is influenced by a decade spent reviewing drug development programmes submitted for European regulatory approval. During the prolonged gestation of a new medicine few candidate molecules survive. This process of elimination of many variants and the survival of so few has much in common with evolution, an analogy that encourages discussion of the forces that favour, and those that hinder, successful drug discovery. Imagining a world without vaccines, anaesthetics, contraception and anti-infectives reveals how medicines revolutionized humanity. How to manipulate conditions that favour such discoveries is worth consideration.

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References

    1. Rosen W. The Most Powerful Idea in the World. A Story of Steam, Industry and Invention. London: Jonathan Cape; 2010. p. 108. 324.
    1. Hughes B. 2009 FDA drug approvals. Nat Rev Drug Discov. 2010;9:89–92. - PubMed
    1. Drake JM, Griffen BD. Early warning signals of extinction in deteriorating environments. Nature. 2010;467:456–9. - PubMed
    1. Eichler H-G, Aronsson B, Abadie E, Salmonson T. New drug approval success rate in Europe in 2009. Nat Rev Drug Discov. 2010;9:355–6. - PubMed
    1. Van Valen L. A new evolutionary law. Evol Theory. 1973;1:1–30.