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Review
. 2009:5:767-74.
doi: 10.2147/vhrm.s5532. Epub 2009 Sep 18.

Antiatherogenic effects of vitamin E: the search for the Holy Grail

Dimitrios Kirmizis  1 , Dimitrios Chatzidimitriou
Affiliations
Review

Antiatherogenic effects of vitamin E: the search for the Holy Grail

Dimitrios Kirmizis et al. Vasc Health Risk Manag. 2009.

Abstract

Vitamin E, a naturally occurring antioxidant, has been found to reduce atherosclerotic lesion formation in animal models as well as cardiovascular morbidity in several observational studies. However, a number of case-control and prospective cohort studies failed to confirm its value in the primary and secondary prevention of morbidity and mortality from coronary artery disease. Several small or larger randomized interventional trials completed to date failed to resolve the conflict. Notably, even in large, well-conducted prospective epidemiologic studies, the potential effects of residual confounding may be on the same order of magnitude as the reported benefit. The response to vitamin E supplementation in specific patient subpopulations with chronic inflammation and/or higher degrees of oxidative stress has not been studied as yet. Therefore, further large randomized interventional trials are warranted to clarify accurately the role of vitamin E in the primary and secondary prevention of atherosclerotic coronary disease in these patient groups.

Keywords: anti-inflammatory; antioxidant; atherosclerosis; cardiovascular disease; vitamin E.

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References

    1. Steinberg D. Oxidative modification of LDL and Atherogenesis. Circulation. 1997;95:1062–1071. - PubMed
    1. Esterbauer H, Gebicki J, Puhl H, Jurgens G. The role of lipid peroxidation and antioxidants in oxidative modification of LDL. Free Radic Biol Med. 1992;13:341–390. - PubMed
    1. Jha P, Flather M, Lonn E, Farkouh M, Yusuf S. The antioxidant vitamins and cardiovascular disease: a critical review of epidemiologic and clinical trial data. Ann Intern Med. 1995;123:860–872. - PubMed
    1. Gey KF, Puska P, Jordan P, Moser UK. Inverse correlation between plasma vitamin E and mortality from ischemic heart disease in cross-cultural epidemiology. Am J Clin Nutr. 1991;53(1 Suppl):326S–334S. - PubMed
    1. Riemersma RA, Wood DA, Macintyre CC, Elton RA, Gey KF, Oliver MF. Risk of angina pectoris and plasma concentrations of vitamins A, C, and E and carotene. Lancet. 1991;337:1–5. - PubMed

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