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. 1999 Sep 1;24(17):1221-3.
doi: 10.1364/ol.24.001221.

In vivo ultrahigh-resolution optical coherence tomography

W Drexler, U Morgner, F X Kärtner, C Pitris, S A Boppart, X D Li, E P Ippen, J G Fujimoto

In vivo ultrahigh-resolution optical coherence tomography

W Drexler et al. Opt Lett. .

Abstract

Ultrahigh-resolution optical coherence tomography (OCT) by use of state of the art broad-bandwidth femtosecond laser technology is demonstrated and applied to in vivo subcellular imaging. Imaging is performed with a Kerr-lens mode-locked Ti:sapphire laser with double-chirped mirrors that emits sub-two-cycle pulses with bandwidths of up to 350 nm, centered at 800 nm. Longitudinal resolutions of ~1mum and transverse resolution of 3mum, with a 110-dB dynamic range, are achieved in biological tissue. To overcome depth-of-field limitations we perform zone focusing and image fusion to construct a tomogram with high transverse resolution throughout the image depth. To our knowledge this is the highest longitudinal resolution demonstrated to date for in vivo OCT imaging.

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