Review
doi: 10.1124/mi.7.2.9.
The pharmacology and signaling of bitter, sweet, and umami taste sensing
Affiliations
- PMID: 17468389
- DOI: 10.1124/mi.7.2.9
Item in Clipboard
Review
The pharmacology and signaling of bitter, sweet, and umami taste sensing
Mol Interv.
2007 Apr.
Abstract
Over the last decade, many of the molecular components that mediate the transduction of taste signaling have been elucidated. The chemosensory receptors for taste have been identified as G protein-coupled receptors (GPCRs) and ion channels that are expressed on the surface of highly specialized taste sensory cells. Tastant molecules act as agonists, binding to and stabilizing active conformations of receptors, resulting in the initiation of signal transduction cascades. Taste signaling, therefore, should be amenable to the methods of pharmacology. This review focuses on the GPCR-mediated signaling of bitter, sweet, and umami tastes and emphasizes the opportunities for pharmacologic evaluation.
Similar articles
-
Taste receptor signalling - from tongues to lungs.Acta Physiol (Oxf). 2012 Feb;204(2):158-68. doi: 10.1111/j.1748-1716.2011.02308.x. Epub 2011 May 7. Acta Physiol (Oxf). 2012. PMID: 21481196 Free PMC article. Review.
-
Expression of gustducin overlaps with that of type III IP3 receptor in taste buds of the rat soft palate.Chem Senses. 2007 Sep;32(7):689-96. doi: 10.1093/chemse/bjm036. Epub 2007 Jun 12. Chem Senses. 2007. PMID: 17566068
-
Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.Cell. 2003 Feb 7;112(3):293-301. doi: 10.1016/s0092-8674(03)00071-0. Cell. 2003. PMID: 12581520
-
Elucidation of mammalian bitter taste.Rev Physiol Biochem Pharmacol. 2005;154:37-72. doi: 10.1007/s10254-005-0041-0. Rev Physiol Biochem Pharmacol. 2005. PMID: 16032395 Review.
-
Mouse taste cells with G protein-coupled taste receptors lack voltage-gated calcium channels and SNAP-25.BMC Biol. 2006 Mar 30;4:7. doi: 10.1186/1741-7007-4-7. BMC Biol. 2006. PMID: 16573824 Free PMC article.
Cited by
-
A sweet cycle for Arabidopsis G-proteins: Recent discoveries and controversies in plant G-protein signal transduction.Plant Signal Behav. 2008 Dec;3(12):1067-76. doi: 10.4161/psb.3.12.7184. Plant Signal Behav. 2008. PMID: 19513240 Free PMC article.
-
The stability of tastant detection by mouse lingual chemosensory tissue requires Regulator of G protein Signaling-21 (RGS21).Chem Senses. 2021 Jan 1;46:bjab048. doi: 10.1093/chemse/bjab048. Chem Senses. 2021. PMID: 34718440 Free PMC article.
-
Development of Full Sweet, Umami, and Bitter Taste Responsiveness Requires Regulator of G protein Signaling-21 (RGS21).Chem Senses. 2018 May 23;43(5):367-378. doi: 10.1093/chemse/bjy024. Chem Senses. 2018. PMID: 29701767 Free PMC article.
-
The Palatability of Lopinavir and Ritonavir Delivered by an Innovative Freeze-Dried Fast-Dissolving Tablet Formulation.AIDS Res Treat. 2018 Jan 17;2018:5908167. doi: 10.1155/2018/5908167. eCollection 2018. AIDS Res Treat. 2018. PMID: 29593900 Free PMC article.
-
The C. elegans cGMP-dependent protein kinase EGL-4 regulates nociceptive behavioral sensitivity.PLoS Genet. 2013;9(7):e1003619. doi: 10.1371/journal.pgen.1003619. Epub 2013 Jul 11. PLoS Genet. 2013. PMID: 23874221 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources