Review
doi: 10.1158/1078-0432.CCR-06-1736.
The hedgehog signaling pathway in cancer
Affiliations
- PMID: 17062662
- DOI: 10.1158/1078-0432.CCR-06-1736
Item in Clipboard
Review
The hedgehog signaling pathway in cancer
Clin Cancer Res.
.
Abstract
The Hedgehog (Hh) pathway is a signaling cascade that directs patterning in most animals and is crucial for proper development. At the molecular level, Hh ligands drive cell proliferation in some cell types while causing others to undergo differentiation. Hh signaling is most active during embryogenesis, and aberrant reactivation of the pathway in adult tissue can lead to the development of cancer. A comprehensive understanding of Hh signaling during development will undoubtedly shed light into the mechanism of Hh in cancer progression and identify potential targets for therapeutic intervention.
Similar articles
-
The hedgehog pathway as a therapeutic target for treatment of breast cancer.Breast Cancer Res Treat. 2009 Jul;116(2):239-46. doi: 10.1007/s10549-009-0423-0. Epub 2009 May 29. Breast Cancer Res Treat. 2009. PMID: 19479372 Review.
-
Hedgehog signalling in skin development and cancer.Exp Dermatol. 2006 Sep;15(9):667-77. doi: 10.1111/j.1600-0625.2006.00473.x. Exp Dermatol. 2006. PMID: 16881963 Review.
-
Intricacies of hedgehog signaling pathways: a perspective in tumorigenesis.Exp Cell Res. 2012 Oct 1;318(16):1959-72. doi: 10.1016/j.yexcr.2012.05.015. Epub 2012 May 31. Exp Cell Res. 2012. PMID: 22659135 Review.
-
Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.Trends Pharmacol Sci. 2009 Jun;30(6):303-12. doi: 10.1016/j.tips.2009.03.007. Epub 2009 May 13. Trends Pharmacol Sci. 2009. PMID: 19443052 Review.
-
Mechanisms of Hedgehog gradient formation and interpretation.J Neurobiol. 2005 Sep 15;64(4):334-56. doi: 10.1002/neu.20168. J Neurobiol. 2005. PMID: 16041759 Review.
Cited by
-
Overexpression of mutant Ptch in rhabdomyosarcomas is associated with promoter hypomethylation and increased Gli1 and H3K4me3 occupancy.Oncotarget. 2015 Apr 20;6(11):9113-24. doi: 10.18632/oncotarget.3272. Oncotarget. 2015. PMID: 25823816 Free PMC article.
-
Evaluation of the 'Hedgehog' signaling pathways in squamous and basal cell carcinomas of the eyelids and conjunctiva.Oncol Lett. 2016 Jul;12(1):467-472. doi: 10.3892/ol.2016.4625. Epub 2016 May 25. Oncol Lett. 2016. PMID: 27347166 Free PMC article.
-
Bench to bedside and back again: molecular mechanisms of alpha-catenin function and roles in tumorigenesis.Semin Cancer Biol. 2008 Feb;18(1):53-64. doi: 10.1016/j.semcancer.2007.08.003. Epub 2007 Sep 4. Semin Cancer Biol. 2008. PMID: 17945508 Free PMC article. Review.
-
Effects of Modulation of the Hedgehog and Notch Signaling Pathways on Osteoblast Differentiation Induced by Titanium with Nanotopography.J Funct Biomater. 2023 Jan 30;14(2):79. doi: 10.3390/jfb14020079. J Funct Biomater. 2023. PMID: 36826878 Free PMC article.
-
Emerging anticancer therapeutic targets and the cardiovascular system: is there cause for concern?Circ Res. 2010 Apr 2;106(6):1022-34. doi: 10.1161/CIRCRESAHA.109.211276. Circ Res. 2010. PMID: 20360265 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
