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Clinical Trial
. 2004 Dec;59(6):357-60.
doi: 10.1590/s0041-87812004000600008. Epub 2005 Jan 11.

Bethanecol chloride for treatment of clomipramine-induced orgasmic dysfunction in males

Márcio Bernik  1 , Antonio Hélio Guerra Vieira, Paula Villela Nunes
Affiliations
Clinical Trial

Bethanecol chloride for treatment of clomipramine-induced orgasmic dysfunction in males

Márcio Bernik et al. Rev Hosp Clin Fac Med Sao Paulo. 2004 Dec.

Abstract

Purpose: To investigate whether bethanecol chloride may be an alternative for the clinical management of clomipramine-induced orgasmic dysfunction, reported to occur in up to 96% of male users.

Methods: In this study, 12 fully remitted panic disorder patients, complaining of severe clomipramine-induced ejaculatory delay, were randomly assigned to either bethanecol chloride tablets (20 mg, as needed) or placebo in a randomized, double-blind, placebo-controlled, two-period crossover study. A visual analog scale was used to assess severity of the orgasmic dysfunction.

Results: A clear improvement was observed in the active treatment period. No placebo or carry-over effects were observed.

Conclusion: These findings suggest that bethanecol chloride given 45 minutes before sexual intercourse may be useful for clomipramine-induced orgasmic dysfunction in males.

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