doi: 10.1021/jm00096a005.
Determination of the absolute configuration of the active amlodipine enantiomer as (-)-S: a correction
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- PMID: 1388206
- DOI: 10.1021/jm00096a005
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Determination of the absolute configuration of the active amlodipine enantiomer as (-)-S: a correction
J Med Chem.
.
Abstract
The active (-) enantiomer of amlodipine was originally reported to have R configuration. This does not concur with other 1,4-dihydropyridines with known absolute configuration. This configuration has now been determined by X-ray structural analysis using (1S)-camphanic acid and (S)-2-methoxy-2-phenylethanol as chiral probes. Both determinations gave the S configuration for the amlodipine (-) enantiomer with the greater Ca-antagonistic activity.
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