Signal transduction by the TGF-beta superfamily
- PMID: 12040180
- DOI: 10.1126/science.1071809
Signal transduction by the TGF-beta superfamily
Abstract
Transforming growth factor-beta (TGF-beta) superfamily members regulate a plethora of developmental processes, and disruption of their activity has been implicated in a variety of human diseases ranging from cancer to chondrodysplasias and pulmonary hypertension. Intense investigations have revealed that SMAD proteins constitute the basic components of the core intracellular signaling cascade and that SMADs function by carrying signals from the cell surface directly to the nucleus. Recent insights have revealed how SMAD proteins themselves are regulated and how appropriate subcellular localization of SMADs and TGF-beta transmembrane receptors is controlled. Current research efforts investigating the contribution of SMAD-independent pathways promise to reveal advances to enhance our understanding of the signaling cascade.
Similar articles
-
TGF-beta and the Smad signal transduction pathway.Biochem Cell Biol. 2002;80(5):605-22. doi: 10.1139/o02-161. Biochem Cell Biol. 2002. PMID: 12440701 Review.
-
NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor.Biochem J. 2005 Mar 15;386(Pt 3):461-70. doi: 10.1042/BJ20040738. Biochem J. 2005. PMID: 15496141 Free PMC article.
-
TGF-beta signaling by Smad proteins.Adv Immunol. 2000;75:115-57. doi: 10.1016/s0065-2776(00)75003-6. Adv Immunol. 2000. PMID: 10879283 Review.
-
The N domain of Smad7 is essential for specific inhibition of transforming growth factor-beta signaling.J Cell Biol. 2001 Dec 10;155(6):1017-27. doi: 10.1083/jcb.200106023. Epub 2001 Dec 10. J Cell Biol. 2001. PMID: 11739411 Free PMC article.
-
How the Smads regulate transcription.Int J Biochem Cell Biol. 2008;40(3):383-408. doi: 10.1016/j.biocel.2007.09.006. Epub 2007 Oct 7. Int J Biochem Cell Biol. 2008. PMID: 18061509 Review.
Cited by
-
Emerging roles of the bone morphogenetic protein pathway in cancer: potential therapeutic target for kinase inhibition.Biochem Soc Trans. 2016 Aug 15;44(4):1117-34. doi: 10.1042/BST20160069. Biochem Soc Trans. 2016. PMID: 27528760 Free PMC article. Review.
-
Cross-talk between EGF and BMP9 signalling pathways regulates the osteogenic differentiation of mesenchymal stem cells.J Cell Mol Med. 2013 Sep;17(9):1160-72. doi: 10.1111/jcmm.12097. Epub 2013 Jul 11. J Cell Mol Med. 2013. PMID: 23844832 Free PMC article.
-
Shifting osteogenesis in vascular calcification.JCI Insight. 2021 May 24;6(10):e143023. doi: 10.1172/jci.insight.143023. JCI Insight. 2021. PMID: 33848269 Free PMC article.
-
SMAD4 mutations causing Myhre syndrome are under positive selection in the male germline.Am J Hum Genet. 2024 Sep 5;111(9):1953-1969. doi: 10.1016/j.ajhg.2024.07.006. Epub 2024 Aug 7. Am J Hum Genet. 2024. PMID: 39116879 Free PMC article.
-
TGFβ-stimulated microRNA-21 utilizes PTEN to orchestrate AKT/mTORC1 signaling for mesangial cell hypertrophy and matrix expansion.PLoS One. 2012;7(8):e42316. doi: 10.1371/journal.pone.0042316. Epub 2012 Aug 3. PLoS One. 2012. PMID: 22879939 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
