Bone morphogenetic protein receptors and signal transduction
- PMID: 19762341
- DOI: 10.1093/jb/mvp148
Bone morphogenetic protein receptors and signal transduction
Abstract
Bone morphogenetic proteins (BMPs) exhibit broad spectra of biological activities in various tissues, including bone, cartilage, blood vessels, heart, kidney, neurons, liver and lung. BMPs are members of the transforming growth factor-beta (TGF-beta) family that bind to type II and type I serine-threonine kinase receptors, and transduce signals through Smad and non-Smad signalling pathways. Recent findings have revealed that BMP signalling is finely tuned by various mechanisms in both positive and negative fashions. Perturbations of BMP signalling pathways are linked to a wide variety of clinical disorders, including vascular diseases, skeletal diseases and cancer. Administration of recombinant BMP ligands and increasing endogenous expression of BMPs provide therapeutic effects on some diseases. The recent development of BMP receptor inhibitors may also prove useful for some clinical diseases induced by hyperactivation of the BMP signalling pathways.
Comment in
-
An impact of CCN2-BMP-2 complex upon chondrocyte biology: evoking a signalling pathway bypasses ERK and Smads?J Biochem. 2011 Sep;150(3):219-21. doi: 10.1093/jb/mvr089. Epub 2011 Jul 18. J Biochem. 2011. PMID: 21768122
Similar articles
-
Bone morphogenetic proteins.Growth Factors. 2004 Dec;22(4):233-41. doi: 10.1080/08977190412331279890. Growth Factors. 2004. PMID: 15621726 Review.
-
Biphasic effects of transforming growth factor β on bone morphogenetic protein-induced osteoblast differentiation.J Bone Miner Res. 2011 Jun;26(6):1178-87. doi: 10.1002/jbmr.313. J Bone Miner Res. 2011. PMID: 21611961
-
Structural insights into BMP receptors: Specificity, activation and inhibition.Cytokine Growth Factor Rev. 2016 Feb;27:13-34. doi: 10.1016/j.cytogfr.2015.11.005. Epub 2015 Nov 24. Cytokine Growth Factor Rev. 2016. PMID: 26690041 Review.
-
BMP signaling in vascular diseases.FEBS Lett. 2012 Jul 4;586(14):1993-2002. doi: 10.1016/j.febslet.2012.04.030. Epub 2012 May 3. FEBS Lett. 2012. PMID: 22710160 Review.
-
Bone Morphogenetic Proteins.Cold Spring Harb Perspect Biol. 2016 Jun 1;8(6):a021899. doi: 10.1101/cshperspect.a021899. Cold Spring Harb Perspect Biol. 2016. PMID: 27252362 Free PMC article. Review.
Cited by
-
BMPER regulates cardiomyocyte size and vessel density in vivo.Cardiovasc Pathol. 2013 May-Jun;22(3):228-40. doi: 10.1016/j.carpath.2012.10.005. Epub 2012 Nov 28. Cardiovasc Pathol. 2013. PMID: 23200275 Free PMC article.
-
Tumor-promoting functions of transforming growth factor-β in progression of cancer.Ups J Med Sci. 2012 May;117(2):143-52. doi: 10.3109/03009734.2011.638729. Epub 2011 Nov 24. Ups J Med Sci. 2012. PMID: 22111550 Free PMC article. Review.
-
Glucagon-like Peptide-1 Improves Fatty Liver and Enhances Thermogenesis in Brown Adipose Tissue via Inhibiting BMP4-Related Signaling Pathway in High-Fat-Diet-Induced Obese Mice.Int J Endocrinol. 2021 Apr 26;2021:6620289. doi: 10.1155/2021/6620289. eCollection 2021. Int J Endocrinol. 2021. PMID: 33986800 Free PMC article.
-
Association of BMPR1A polymorphism, but not BMP4, with kidney size in full-term newborns.Pediatr Nephrol. 2013 Mar;28(3):433-8. doi: 10.1007/s00467-012-2277-7. Epub 2012 Aug 11. Pediatr Nephrol. 2013. PMID: 22886282 Free PMC article.
-
The Heparan Sulfate Proteoglycan Glypican-6 Is Upregulated in the Failing Heart, and Regulates Cardiomyocyte Growth through ERK1/2 Signaling.PLoS One. 2016 Oct 21;11(10):e0165079. doi: 10.1371/journal.pone.0165079. eCollection 2016. PLoS One. 2016. PMID: 27768722 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
