Download scientific diagram | Cell cycle component expression and requirement during embryonic brain development. Cdk1 is the only Cdk required for adequate embryonic development, since suppression of its expression causes mice to fail in reaching morula and blastocyst stages, while mouse embryos lacking all the interphase Cdks only develop to midgestation. Cyclin D1 is expressed mainly at early stages of the brain development, and its expression decreases progressively till adulthood, being...