<p>Open for Submissions</p> <p>Publishing high-quality research on systems-oriented biological approaches.</p> <p><em>npj Systems Biology and Applications</em> is a fully open-access journal that aims to provide a forum for articles that help define the nascent field of systems biology, as well as those that apply the advances to wider fields.</p> <p><em>npj Systems Biology and Applications</em> covers topics including, but not limited to, network biology, application of control theory to biological systems, computational modelling and analysis, comprehensive and/or high-content measurements, theoretical, analytical and computational studies of system-level properties of biological systems and computational/software/data platforms enabling such studies.</p> <p>In addition to original research, the journal welcomes critical Reviews, and thought-provoking Perspectives and Comment articles.</p> http://feeds.nature.com/npjsba/rss/current Nature Publishing Group en © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. npj Systems Biology and Applications © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. [email protected]

https://www.nature.com/uploads/product/npjsba/rss.png http://feeds.nature.com/npjsba/rss/current https://www.nature.com/articles/s41540-026-00648-9 npj Systems Biology and Applications, Published online: 29 January 2026; doi:10.1038/s41540-026-00648-9Simulation-based inference of cell migration dynamics in complex spatial environments]]> Jonas ArrudaEmad AlamoudiRobert MuellerMarc VaisbandRonja MolkenburJack MerrinEva KiermaierJan Hasenauer doi:10.1038/s41540-026-00648-9 npj Systems Biology and Applications, Published online: 2026-01-29; | doi:10.1038/s41540-026-00648-9 2026-01-29 npj Systems Biology and Applications 10.1038/s41540-026-00648-9 https://www.nature.com/articles/s41540-026-00648-9 https://www.nature.com/articles/s41540-026-00653-y npj Systems Biology and Applications, Published online: 28 January 2026; doi:10.1038/s41540-026-00653-yDynamical network analysis reveals long-range residue couplings at the pMHC interface underlying enhanced immunogenicity]]> Tom ResinkBenedetta Maria SalaRenhua SunXiao HanEvren AliciFlavio Salazar-OnfrayTatyana SandalovaCheng ZhangHans-Gustaf LjunggrenAdnane Achour doi:10.1038/s41540-026-00653-y npj Systems Biology and Applications, Published online: 2026-01-28; | doi:10.1038/s41540-026-00653-y 2026-01-28 npj Systems Biology and Applications 10.1038/s41540-026-00653-y https://www.nature.com/articles/s41540-026-00653-y https://www.nature.com/articles/s41540-026-00654-x npj Systems Biology and Applications, Published online: 27 January 2026; doi:10.1038/s41540-026-00654-xSpatial FBA reveals heterogeneous Warburg niches in renal tumors and lactate consumption in colorectal cancer]]> Davide MasperoGiovanni MartelettoFrancesco LapiBruno G. GaluzziIrene RuanoBen VandenboschKe YinSabine TejparAlex GraudenziHolger HeynAnna Pascual-ReguantChiara Damiani doi:10.1038/s41540-026-00654-x npj Systems Biology and Applications, Published online: 2026-01-27; | doi:10.1038/s41540-026-00654-x 2026-01-27 npj Systems Biology and Applications 10.1038/s41540-026-00654-x https://www.nature.com/articles/s41540-026-00654-x https://www.nature.com/articles/s41540-026-00656-9 npj Systems Biology and Applications, Published online: 26 January 2026; doi:10.1038/s41540-026-00656-9The future of mathematical oncology in the age of AI]]> Russell C. RockneMorten AndersenAlexander R. A. AndersonDavid BasantaAngela BentivegnaSebastien BenzekrySergio BranciamoreSarah C. BrüningkMartina ConteFarnoush FarahpourAleksandra KarolakAlvaro Köhn-LuqueGuillermo LorenzoBabgen ManookianAndrei S. RodinLara SchmalenstroerJuan SolerCristian TomasettiKonstancja Urbaniak doi:10.1038/s41540-026-00656-9 npj Systems Biology and Applications, Published online: 2026-01-26; | doi:10.1038/s41540-026-00656-9 2026-01-26 npj Systems Biology and Applications 10.1038/s41540-026-00656-9 https://www.nature.com/articles/s41540-026-00656-9 https://www.nature.com/articles/s41540-026-00650-1 npj Systems Biology and Applications, Published online: 26 January 2026; doi:10.1038/s41540-026-00650-1In silico modeling of anterior foregut endoderm differentiation towards lung epithelial progenitors]]> Amirmahdi MostofinejadDavid A. RomeroDana BrinsonThomas K. WaddellGolnaz KaroubiCristina H. Amon doi:10.1038/s41540-026-00650-1 npj Systems Biology and Applications, Published online: 2026-01-26; | doi:10.1038/s41540-026-00650-1 2026-01-26 npj Systems Biology and Applications 10.1038/s41540-026-00650-1 https://www.nature.com/articles/s41540-026-00650-1 https://www.nature.com/articles/s41540-026-00655-w npj Systems Biology and Applications, Published online: 25 January 2026; doi:10.1038/s41540-026-00655-wCanalization as a stabilizing principle of gene regulatory networks: a discrete dynamical systems perspective]]> Claus Kadelka doi:10.1038/s41540-026-00655-w npj Systems Biology and Applications, Published online: 2026-01-25; | doi:10.1038/s41540-026-00655-w 2026-01-25 npj Systems Biology and Applications 10.1038/s41540-026-00655-w https://www.nature.com/articles/s41540-026-00655-w https://www.nature.com/articles/s41540-025-00638-3 npj Systems Biology and Applications, Published online: 20 January 2026; doi:10.1038/s41540-025-00638-3Machine learning prediction for AML based on 3D genome selected circRNA]]> Zhangli YuanWenqian YanRuoyao WangShanshan YinChongchen PangXinyuan RenWenchang DuanMika TorholaKlaus FörgerHenna KujanenYixin ZhangHaoyan ChenHui ShiYuqing LouHao LiGuang HeYi Shi doi:10.1038/s41540-025-00638-3 npj Systems Biology and Applications, Published online: 2026-01-20; | doi:10.1038/s41540-025-00638-3 2026-01-20 npj Systems Biology and Applications 10.1038/s41540-025-00638-3 https://www.nature.com/articles/s41540-025-00638-3 https://www.nature.com/articles/s41540-025-00640-9 npj Systems Biology and Applications, Published online: 20 January 2026; doi:10.1038/s41540-025-00640-9Gene regulatory network transitions reveal the central transcription factors in lung adenocarcinoma progression]]> Upasana RayAdarsh SinghDebabrata SamantaRiddhiman Dhar doi:10.1038/s41540-025-00640-9 npj Systems Biology and Applications, Published online: 2026-01-20; | doi:10.1038/s41540-025-00640-9 2026-01-20 npj Systems Biology and Applications 10.1038/s41540-025-00640-9 https://www.nature.com/articles/s41540-025-00640-9