How long will we live? And how much of that time will comprise a healthy life? What is aging, and can we stop or even reverse the aging process? What is the connection between aging and disease? Can we predict the evolving trends in the aging of human populations and prepare our societies for what has been called the Silver Tsunami? These are some of the important questions that the broad field of aging research is trying to address and that together form one of the Grand Challenges of the twenty-first century. The mission of Nature Aging is to provide a unique multidisciplinary, unifying and highly visible publishing platform for the aging-research community. The journal is highly selective yet broad in its coverage, publishing research from across the entire spectrum of the field, ranging from the basic biology of aging to the impact of aging on society. The journal aims to foster interactions among different areas of this diverse field of research and to promote new and exciting ideas within and beyond the research community, to enable synergy and maximize scientific and societal impact. http://feeds.nature.com/nataging/rss/current Nature Publishing Group en © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Aging © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. [email protected]

https://www.nature.com/uploads/product/nataging/rss.gif http://feeds.nature.com/nataging/rss/current https://www.nature.com/articles/s43587-026-01064-8 Nature Aging, Published online: 29 January 2026; doi:10.1038/s43587-026-01064-8Studies of biomarkers of aging encounter a range of epidemiological and methodological challenges, many of which are not fully acknowledged. In this Comment, we critically examine key challenges and suggest strategies to address them.]]> Thaís Lopes de OliveiraNancy L. PedersenJoris DeelenSara Hägg doi:10.1038/s43587-026-01064-8 Nature Aging, Published online: 2026-01-29; | doi:10.1038/s43587-026-01064-8 2026-01-29 Nature Aging 10.1038/s43587-026-01064-8 https://www.nature.com/articles/s43587-026-01064-8 https://www.nature.com/articles/s43587-025-01057-z Nature Aging, Published online: 29 January 2026; doi:10.1038/s43587-025-01057-zWakita et al. systematically compare the efficacy of 21 senolytics and identify a subpopulation of senolytic-resistant cells. They demonstrate a mitochondrial basis of senolytic resistance and show that metabolic interventions enhance senescent cell clearance in vivo.]]> Masahiro WakitaKoyu ItoKaho FujiiDai SakamotoTakumi MikawaSho SugawaraXiangyu ZhouJeong Hoon ParkHideka MiyagawaDaisuke MotookaEmi OgasawaraNaotada IshiharaAkiko TakahashiHiroshi KondohEiji Hara doi:10.1038/s43587-025-01057-z Nature Aging, Published online: 2026-01-29; | doi:10.1038/s43587-025-01057-z 2026-01-29 Nature Aging 10.1038/s43587-025-01057-z https://www.nature.com/articles/s43587-025-01057-z https://www.nature.com/articles/s43587-026-01079-1 Nature Aging, Published online: 28 January 2026; doi:10.1038/s43587-026-01079-1Publisher Correction: Shear stress governs hematopoietic stem cell fate to promote inflammation-induced aging]]> Tongyao ShangLi ZhaoShibo YingLida SuYue YangJiadong LiuYingying WangJipeng XueCheng ChengYixin WuShiyao ChenHongmei DongXuequn ChenHailin MaQi ZhangTingbo LiangWei YangYe FengMarong FangXinjiang Lu doi:10.1038/s43587-026-01079-1 Nature Aging, Published online: 2026-01-28; | doi:10.1038/s43587-026-01079-1 2026-01-28 Nature Aging 10.1038/s43587-026-01079-1 https://www.nature.com/articles/s43587-026-01079-1 https://www.nature.com/articles/s43587-025-01056-0 Nature Aging, Published online: 22 January 2026; doi:10.1038/s43587-025-01056-0LINE-1 retrotransposons are implicated in aging, but their role in cardiac aging specifically is not well understood. Here the authors show that LINE-1 expression rises in mouse hearts with age. Genetic LINE-1 derepression is accompanied by cGAS–STING activation and cardiac dysfunction, while pharmacological inhibition of LINE-1 or STING improves cardiac function in aged mice.]]> Chaofan YangHeng DuSiqi LiuPengfei XuYuhan WangYanan ZhouHailong YuanYujing LiJianghua ShenXiaosu YuanMei LiChuting HeJiahe ZhangYi XiaoJinmiao BiYu HouJingyi ZangZeyu GaoMoshi Song doi:10.1038/s43587-025-01056-0 Nature Aging, Published online: 2026-01-22; | doi:10.1038/s43587-025-01056-0 2026-01-22 Nature Aging 10.1038/s43587-025-01056-0 https://www.nature.com/articles/s43587-025-01056-0 https://www.nature.com/articles/s43587-025-01062-2 Nature Aging, Published online: 21 January 2026; doi:10.1038/s43587-025-01062-2As we embark on our sixth year of publication, we reflect on what the journal has achieved and highlight some of its successes. This anniversary issue also features two Q&As. One pulls back the curtain on the work of the journal’s backstage team. The other samples the thoughts and opinions of some of the many researchers who supported the journal early on, as authors, advisers or reviewers.]]> doi:10.1038/s43587-025-01062-2 Nature Aging, Published online: 2026-01-21; | doi:10.1038/s43587-025-01062-2 2026-01-21 Nature Aging 10.1038/s43587-025-01062-2 https://www.nature.com/articles/s43587-025-01062-2 https://www.nature.com/articles/s43587-025-01049-z Nature Aging, Published online: 21 January 2026; doi:10.1038/s43587-025-01049-zFor Nature Aging’s fifth anniversary, we acknowledge the essential work that is done by our colleagues, without which Nature Aging’s monthly publication would not be possible. We speak with some of our internal colleagues about the process of making a journal every month. Rebecca Roberts is a production editor at Springer Nature, Mark McGranaghan is a senior sub editor, Lauren Snape is an art editor and Amanda Karmolinski is a senior editorial assistant. In this Q&A, Rebecca, Mark, Lauren and Amanda pull back the curtain and tell us about the various roles that go into putting it all together.]]> Rebecca RobertsMark McGranaghanLauren SnapeAmanda KarmolinskiQingzhong RenHannah WaltersYahyah AmanSebastien ThuaultAnna Kriebs doi:10.1038/s43587-025-01049-z Nature Aging, Published online: 2026-01-21; | doi:10.1038/s43587-025-01049-z 2026-01-21 Nature Aging 10.1038/s43587-025-01049-z https://www.nature.com/articles/s43587-025-01049-z https://www.nature.com/articles/s43587-025-01046-2 Nature Aging, Published online: 21 January 2026; doi:10.1038/s43587-025-01046-2As Nature Aging celebrates its fifth anniversary, the journal asks some of the researchers who contributed to the journal early on to reflect on the past and the future of aging and age-related disease research, the impact of the field on human health now and in the future, and what challenges need to be addressed to ensure sustained progress.]]> Fabrisia AmbrosioMaxim N. ArtyomovSteven N. AustadNir BarzilaiJuan Carlos Izpisua BelmonteDaniel W. BelskyBérénice A. BenayounAnne BrunetHandan Melike DönertaşDena B. DubalEvandro F. FangJerome N. FeigeLinda P. FriedDavid FurmanXu GaoVadim N. GladyshevVera GorbunovaMyriam GorospeJing-Dong J. HanOskar HanssonEiji HaraSteve HorvathNancy Y. IpGeorge A. KuchelMatt KaeberleinDudley W. LammingBecca R. LevyGuang-Hui LiuJinkook LeeTerrie E. MoffittTohru MinaminoLinda PartridgeParminder RainaThomas A. RandoJohn W. RoweMichal SchwartzAndrew J. ScottFelipe SierraDavid A. SinclairCharlotte E. TeunissenBruno VellasEric VerdinKeenan A. WalkerAshley E. WebbTony Wyss-CorayMing XuJin-Tai YuAlex ZhavoronkovYahyah AmanAnna KriebsQingzhong RenHannah WaltersSebastien Thuault doi:10.1038/s43587-025-01046-2 Nature Aging, Published online: 2026-01-21; | doi:10.1038/s43587-025-01046-2 2026-01-21 Nature Aging 10.1038/s43587-025-01046-2 https://www.nature.com/articles/s43587-025-01046-2 https://www.nature.com/articles/s43587-025-01035-5 Nature Aging, Published online: 21 January 2026; doi:10.1038/s43587-025-01035-5This Perspective proposes the Population Neuroscience-Dementia Syndemics Framework and model to develop knowledge of how multiple factors may interact to perpetuate inequities in dementia, especially for women in low- and middle-income countries.]]> C. Elizabeth ShaabanVidyani SuryadevaraAshley V. HillSadaf Arefi MilaniPuja AgarwalNeelum T. AggarwalRufus O. AkinyemiSuvarna AlladiMonique J. BrownJessica Z. K. CaldwellPaulo CaramelliLyndsey DuBoseRatnavalli EllajosyulaDarlingtina K. EsiakaAllison GibsonPatrick GriffithJoshua HarperWambūi KaranjaWei LiJorge J. Llibre-GuerraSamantha M. LoiMichelle M. MielkeDoris P. Molina-HenryAdesola OgunniyiShehroo PudumjeeShana D. StitesErin SundermannArlener D. TurnerClara Vila-CastelarJayalakshmi ViswanathanJean-François TraniGanesh M. Babulal doi:10.1038/s43587-025-01035-5 Nature Aging, Published online: 2026-01-21; | doi:10.1038/s43587-025-01035-5 2026-01-21 Nature Aging 10.1038/s43587-025-01035-5 https://www.nature.com/articles/s43587-025-01035-5