Monatepil

Monatepil
Names
	IUPAC name (RS)-N-(6,11-dihydrobenzo[c][1]benzothiepin-11-yl)-4-[4-(4-fluorophenyl)-1-piperazinyl]butanamide
Identifiers
CAS Number	103379-03-9
ChemSpider	54798
Jmol interactive 3D	Image
KEGG	D01171
PubChem	60810
UNII	N4MMI0J7PW
	InChI InChI=1S/C28H30FN3OS/c29-22-11-13-23(14-12-22)32-18-16-31(17-19-32)15-5-10-27(33)30-28-24-7-2-1-6-21(24)20-34-26-9-4-3-8-25(26)28/h1-4,6-9,11-14,28H,5,10,15-20H2,(H,30,33) Key: WFNRNNUZFPVBSM-UHFFFAOYSA-N ; InChI=1/C28H30FN3OS/c29-22-11-13-23(14-12-22)32-18-16-31(17-19-32)15-5-10-27(33)30-28-24-7-2-1-6-21(24)20-34-26-9-4-3-8-25(26)28/h1-4,6-9,11-14,28H,5,10,15-20H2,(H,30,33) Key: WFNRNNUZFPVBSM-UHFFFAOYAJ ;
	SMILES C1CN(CCN1CCCC(=O)NC2C3=CC4=CC=C3CSC4=CC=CC=C24)C5=CC=C(C=C5)F ;
Properties
Chemical formula	C28H30FN3OS
Molar mass	475.620703 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

Monatepil is a calcium channel blocker and α₁-adrenergic receptor antagonist used as an antihypertensive.^[1]

Synthesis[edit]

Monatepil synthesis^[2]

^ Sugimoto T, Hosoki K, Karasawa T (July 1995). "Relative contribution of alpha 1-adrenoceptor blocking activity to the hypotensive effect of the novel calcium antagonist monatepil". Journal of Cardiovascular Pharmacology 26 (1): 55–60. doi:10.1097/00005344-199507000-00009. PMID 7564365.
^ Kurokawa, M.; Sato, F.; Fujiwara, I.; Hatano, N.; Honda, Y.; Yoshida, T.; Naruto, S.; Mastumoto, J.; Uno, H. (1991). "A new class of calcium antagonists. 2. Synthesis and biological activity of 11-[4-[4-(4-fluorophenyl)-1-piperazinyl]butyryl]amino]-6,11-dihydrodibenzo[b,e]thiepin maleate and related compounds". Journal of Medicinal Chemistry 34 (3): 927. doi:10.1021/jm00107a009.

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