Talipexole
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| Systematic (IUPAC) name | |
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6-allyl-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[4,5-d]azepin-2-amine
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| Clinical data | |
| Trade names | Domin |
| AHFS/Drugs.com | International Drug Names |
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| Routes of administration |
Oral |
| Identifiers | |
| CAS Number | 36085-73-1  |
| ATC code | None |
| PubChem | CID: 5374 |
| IUPHAR/BPS | 5442 |
| ChemSpider | 5181 |
| UNII | 7AM2J46Z1Y |
| ChEMBL | CHEMBL1289023 |
| Synonyms | Alefexole |
| Chemical data | |
| Formula | C10H15N3S |
| Molecular mass | 209.31 g/mol |
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Talipexole (B-HT920, Domnin) is a dopamine agonist that is marketed as a treatment for Parkinson's Disease in Japan by Boehringer Ingelheim; it was introduced in 1996.[1] As of December 2014 it was not approved for marketing in the US nor in Europe.[2]
Talipexole is a D2 dopamine receptor agonist and interacts both pre- and post-synaptic receptors. It also is an α2-adrenergic agonist.[3]
The main side effects are drowsiness, dizziness, hallucinations and minor gastrointestinal complaints.[3] In 2008 the Japanese Ministry of Health, Labour, and Welfare mandated that Boehringer add a warning to the label concerning the risk of sudden onset of sleep.[4]:15
References[edit]
- ^ PharmaLetter 22 July 1996 First Launch In Japan For Talipexole
- ^ EvaluatePharma Database. Page accessed 9 December 2014
- ^ a b Benkert O, et al. Dopamine agonists in schizophrenia: a review. Eur Neuropsychopharmacol. 1995;5 Suppl:43-53. PMID 8775758
- ^ Japanese Ministry of Health, Labour and Welfare March 2008 Pharmaceuticals and Medical Devices Safety Information No. 245
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