Acta Pharmacologica Sinica

Structure genomics of SARS-CoV-2 and its Omicron variant

New advances in small molecule drugs targeting NMDA receptors

Yue Zeng
Zhi-yan Qu
Zhao-bing Gao

Review Article 04 November 2025

Featured

Targeting the interactions between neutrophils and microglia: a novel strategy for anti-inflammatory treatment of stroke

Long-rui Wang
Zi-yuan Zhao
Ling-lei Kong
Review Article01 Oct 2025
Lung memory B cells ameliorate Alzheimerâ€™s disease-like pathology in 5Ã—FAD mice through the CXCL12-CXCR4 axis

Yan-li Zhang
Shi-xin Ding
Gang Hu
Article17 Oct 2025
The mGluR2/3 agonist xanthurenic acid improves memory, attention, and synaptic deficits by modulating glutamate release in Alzheimerâ€™s disease model

Kyonghwan Choe
Jawad Ali
Myeong Ok Kim
ArticleOpen Access03 Nov 2025
Structure-activity relationship of prevalent synthetic cannabinoid metabolites on hCB₁ in vitro and in silico dynamics

Anna Ã…strand
Emiliano Laudadio
Henrik GrÃ©en
ArticleOpen Access03 Nov 2025

Current issue

Neuroglia and immune cells play different roles in neuroinflammation and neuroimmune response in post-stroke neural injury and repair

Hui Guo
Wen-cao Liu
Pan-pan Geng
Review Article12 Aug 2025
Selective recognition memory impairment in mitochondrial hydroxylase Clk1 mutant mice, rescued by antipsychotics

Zhi-feng Shi
Zhe-xiang Yu
Xue-chu Zhen
Article01 Sept 2025
Galangin, a novel Kv7 potassium channel opener, exerts potent antinociceptive effects in multiple chronic pain mouse models

Bo Yang
Hui Liu
Fan Zhang
Article07 Aug 2025
BMP1 inhibitor UK383367 improves MI-induced cardiac remodeling and fibrosis in mice via ameliorating macrophage polarization and mitochondrial dysfunction

Cheng-hu Guo
Qian-qian Wang
Mei Ni
Article02 Sept 2025
Fumarate hydratase ameliorates pressure overload induced cardiac remodeling by controlling Elovl7-mediated biosynthesis of unsaturated fatty acids

Lan-lan Li
Chao-jun Sun
Wei Deng
Article12 Sept 2025
Inhibition of Setd7 protects against cardiomyocyte hypertrophy via inhibiting lipid oxidation

Hai-bi Su
Jing-huan Wang
Xin-hua Liu
Article12 Aug 2025

Contents

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Announcements

Editorial Excellence

Acta Pharmacologica Sinica, among the top 25% qualifying journals, is recognized for its exceptional editorial excellence, based on data collected from the 2024 Journal Author Satisfaction survey. Congratulations to the Acta Pharmacologica Sinica editors!

Browse articles

Intergenerational effects of the microbiota on neurodevelopment: mechanisms and therapeutic perspectives

Ruo-xi Wang
Ali Afzal
Xin-an Liu
Review Article23 Jan 2026
Protopanaxatriol restores cognitive function in okadaic acid-treated mice via direct inhibition of pathological CDK5 activity

Ye Peng
Sha-sha Wang
Nai-hong Chen
Article21 Jan 2026
A novel photosensitizer berberine derivative B12 induces apoptosis and suppresses HIF-1Î± expression in colorectal cancer cells via mitochondria-to-nucleus sequential-targeting

Wen-bin Pei
Zi-yu Lei
Bei-bei Xu
Article20 Jan 2026
Zinc finger BED-type containing 6 (ZBED6) ameliorates cardiac fibrosis by inhibiting Piezo1 transcription and YAP nuclear translocation

Han Wu
Wei-tao Jiang
Yu Bian
ArticleOpen Access19 Jan 2026
Targeting intrinsic and CAF-mediated signaling by PI3KÎ± inhibitor CYH33 attenuated metastasis in lung squamous cell carcinoma

Xiao-yu Ma
Jie-ting Deng
Ling-hua Meng
Article16 Jan 2026
PPARÎ²/Î´ contributes to the antidiabetic effect and the increase in GDF15 caused by metformin

Javier Jurado-Aguilar
Emma Barroso
Manuel VÃ¡zquez-Carrera
Article16 Jan 2026
MicroRNA-129-5p in the mPFC is involved in the chronic mild stress-induced depression-like behaviors in rats

Jing-yi Xu
Chen-chen Li
Yu-tao Yang
Article16 Jan 2026
UBC9-mediated p53 SUMOylation drives tubular senescence and exacerbates acute kidney injury in mice

Qi-mei Wu
Jing Liu
Zhou-ke Tan
Article16 Jan 2026
Morchella polysaccharide ameliorates myocardial infarction inflammation in mice through increasing gut microbiota-derived 12-HEPE

Hui-min Su
Jia-xin Li
Li-kun Ma
Article16 Jan 2026

In this collection, we present a selection of artificial intelligence (AI)-driven breakthroughs in ion channel drug discovery, featuring studies recognized in the 2023 Shanghai International Computational Biology Challengeâ€”â€œLingyueâ€ Challenge of AI Algorithms for Drug Screening. We hope these works will offer unique insights into AI-enabled ion channel research and inspire future innovation.

Collection 25 Dec 2025

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INRAE is recruiting 49 research scientists through open competitions, from January 27 to March 5, 2026.

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INRAE (France)
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Seeking exceptional Senior/Junior PIs, Postdocs, and Core Specialists globally year-round

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Physician-Scientist Positions in Research Hospital, ShanghaiTech University

Invites visionary Physician-Scientists and Clinicians across all disciplines and career stages to join our foundational team.

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School of Creativity and Art (SCA) calls for candidates with exceptional academic records or demonstrated potential.

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ShanghaiTech University

This journal is a member of and subscribes to the principles of the Committee on Publication Ethics.

New advances in small molecule drugs targeting NMDA receptors

Featured

Targeting the interactions between neutrophils and microglia: a novel strategy for anti-inflammatory treatment of stroke

Lung memory B cells ameliorate Alzheimerâ€™s disease-like pathology in 5Ã—FAD mice through the CXCL12-CXCR4 axis

The mGluR2/3 agonist xanthurenic acid improves memory, attention, and synaptic deficits by modulating glutamate release in Alzheimerâ€™s disease model

Structure-activity relationship of prevalent synthetic cannabinoid metabolites on hCB₁ in vitro and in silico dynamics

Current issue

Neuroglia and immune cells play different roles in neuroinflammation and neuroimmune response in post-stroke neural injury and repair

Selective recognition memory impairment in mitochondrial hydroxylase Clk1 mutant mice, rescued by antipsychotics

Galangin, a novel Kv7 potassium channel opener, exerts potent antinociceptive effects in multiple chronic pain mouse models

BMP1 inhibitor UK383367 improves MI-induced cardiac remodeling and fibrosis in mice via ameliorating macrophage polarization and mitochondrial dysfunction

Fumarate hydratase ameliorates pressure overload induced cardiac remodeling by controlling Elovl7-mediated biosynthesis of unsaturated fatty acids

Inhibition of Setd7 protects against cardiomyocyte hypertrophy via inhibiting lipid oxidation

Announcements

Editorial Excellence

Browse articles

Intergenerational effects of the microbiota on neurodevelopment: mechanisms and therapeutic perspectives

Protopanaxatriol restores cognitive function in okadaic acid-treated mice via direct inhibition of pathological CDK5 activity

A novel photosensitizer berberine derivative B12 induces apoptosis and suppresses HIF-1Î± expression in colorectal cancer cells via mitochondria-to-nucleus sequential-targeting

Zinc finger BED-type containing 6 (ZBED6) ameliorates cardiac fibrosis by inhibiting Piezo1 transcription and YAP nuclear translocation

Targeting intrinsic and CAF-mediated signaling by PI3KÎ± inhibitor CYH33 attenuated metastasis in lung squamous cell carcinoma

PPARÎ²/Î´ contributes to the antidiabetic effect and the increase in GDF15 caused by metformin

MicroRNA-129-5p in the mPFC is involved in the chronic mild stress-induced depression-like behaviors in rats

UBC9-mediated p53 SUMOylation drives tubular senescence and exacerbates acute kidney injury in mice

Morchella polysaccharide ameliorates myocardial infarction inflammation in mice through increasing gut microbiota-derived 12-HEPE

Collections

Artificial Intelligence for Ion Channel Drug Discovery

Trending - Altmetric

Science jobs

Research Scientists

Global Recruitment for Faculty, Postdocs, and Specialists at Hangzhou Institute of Medicine, CAS

Physician-Scientist Positions in Research Hospital, ShanghaiTech University

Faculty Positions (School of Biomedical Engineering (BME))

Faculty Positions (School of Creativity and Art (SCA))

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Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

Recent advances in dopaminergic strategies for the treatment of Parkinsonâ€™s disease

Î²-Hydroxybutyrate improves glymphatic system function and alleviates cerebral edema in mice after ischemic stroke

Targeting intrinsic and CAF-mediated signaling by PI3KÎ± inhibitor CYH33 attenuated metastasis in lung squamous cell carcinoma

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