Candidozyma and Cryptococcus Fungal Data now in the Multiple Comparative Genome Viewer (MCGV)!

NCBI’s Multiple Comparative Genome Viewer (MCGV) continues to expand available alignments! We are excited to announce the addition of two new fungal datasets: Candidozyma auris and Cryptococcus multigenome sequence alignments.

You can now visualize and compare multiple whole genome assemblies for these human pathogens, zooming in on specific genes, tracking evolutionary changes, and identifying critical nucleotide differences across a variety of fungal strains. Continue reading “Candidozyma and Cryptococcus Fungal Data now in the Multiple Comparative Genome Viewer (MCGV)!” →

Coming Soon: Updated PubMed Central (PMC) E-Utilities

PubMed Central (PMC) is moving to an updated version of the E-utilities API in early February 2026. This version of E-utilities will use the same technology as the updated PMC website search, which was released in September 2025. This change means search results returned by the updated ESearch E-utility will now match those of the PMC website.

Next steps

If you manage code that creates PMC E-utility requests, review the changes below to ensure that your code will continue to function after the update. This update only affects E-utility calls when the request specifies the PMC database, &db=pmc. There are no changes to the E-utilities for other databases. Continue reading “Coming Soon: Updated PubMed Central (PMC) E-Utilities” →

Top Posts of 2025: A Look at the NCBI Insights Blog

GenBank Release 269.0

GenBank release 269.0 (12/16/2025) is now available on the NCBI FTP site. This release has 49.73 trillion bases and 6.03 billion records.

The current release has:

259,677,058 traditional records containing 6,651,459,875,408 base pairs of sequence data
4,540,323,299 WGS records containing 42,125,323,988,215 base pairs of sequence data
1,033,885,396 bulk-oriented TSA records containing 878,730,431,459 base pairs of sequence data
190,904,203 bulk-oriented TLS records containing 78,916,795,339 base pairs of sequence data Continue reading “GenBank Release 269.0” →

Upcoming Change in My Bibliography

Use of earliest publication date for determining NIH Public Access compliance

As shared in the July National Center for Biotechnology Information (NCBI) Insights post, NCBI at the National Library of Medicine (NLM) is making ongoing improvements to several offerings to support implementation of the 2024 NIH Public Access Policy.

Effective October 1, 2025, My Bibliography will begin using the earliest publication date listed in PubMed records (whether print or electronic) in support of implementation of the 2024 NIH Public Access Policy update, which defines the Official Date of Publication as:

“The date on which the Final Published Article is first made available in final, edited form, whether in print or electronic (i.e., online) format.” Continue reading “Upcoming Change in My Bibliography” →

An Updated Bacterial and Archaeal Reference Genome Collection is Available!

Download the updated bacterial and archaeal reference genome collection! We built this collection of 22,082 genomes by selecting the “best” genome assembly for each species among the 440,000+ prokaryotic genomes in RefSeq.

What’s new?

28 species are represented in this collection for the first time
228 species are represented by a better assembly
Six species were removed because of changes in NCBI Taxonomy or uncertainty in their species assignment

Continue reading “An Updated Bacterial and Archaeal Reference Genome Collection is Available!” →

GenBank Release 268.0 is Available!

GenBank release 268.0 (8/18/2025) is now available on the NCBI FTP site. This release has 47.01 trillion bases and 5.90 billion records.

The current release has:

258,320,620 traditional records containing 5,676,067,778,413 base pairs of sequence data
4,441,331,387 WGS records containing 40,390,433,406,298 base pairs of sequence data
1,010,159,820 bulk-oriented TSA records containing 864,483,775,194 base pairs of sequence data
190,505,830 bulk-oriented TLS records containing 78,568,415,110 base pairs of sequence data

Continue reading “GenBank Release 268.0 is Available!” →

Upcoming Changes to GenBank Project Lists and Symlinks

The volume of GenBank WGS, TSA, and TLS data sets is large and continues to grow rapidly. To help you identify and retrieve newly released data, we began providing symlinks and project list files in the Index of /genbank/daily-nc area approximately 12 years ago.

What’s new?

As the number of projects and files increases, the current symlink and project list mechanisms have resulted in FTP performance issues when retrieving data. Continue reading “Upcoming Changes to GenBank Project Lists and Symlinks” →

PubMed Central (PMC) Beta Search to Replace Current Search

Coming the week of September 7th

The new PubMed Central (PMC) Beta search will replace the current PMC search the week of September 7, 2025.

As previously announced, the National Library of Medicine (NLM) National Center for Biotechnology Information (NCBI) is working on an update to PMC full-text search functionality and user experience. To prepare for this transition, we released a Beta version in April for you to preview and test. Based on your input, we have already made several improvements. There is still time to provide feedback; we invite you to try out PMC Beta search now and let us know what you think! Continue reading “PubMed Central (PMC) Beta Search to Replace Current Search” →

Now Live: Improved Representation of Functional Data in ClinVar!

ClinVar is pleased to announce that our improved representation of functional data is live on the website, in file submissions, and in downloadable XML files. The following documentation is provided to facilitate future submissions and downloads:

Continue reading “Now Live: Improved Representation of Functional Data in ClinVar!” →